Scientists in Japan have gained a better picture of how the second outermost layer of the skin is created.

The layer of skin called the dermis was grown by the scientists in a lab using a certain type of stem cell from mice.

It is in the dermis where hair follicles, sebaceous and sweat glands are found, and this skin layer is the most difficult layer to heal completely. It cannot heal without scarring.

The Japanese scientists were able to both cultivate and transplant the dermis, with all its various internal structures.

The research may eventually have implications for different types of skin grafts for transplanting and for surgery in general.

Since it is essential to know what genes and neurotransmitters that are vital when dermis skin cells are created.

“Further optimization of our technique using in vitro stem cell culture and humanization will contribute to the development of the therapy by using [the] bioengineered integumentary organ system as a prominent class of organ system replacement regenerative therapy,” said Dr. Takashi Tsuji of the RIKEN Center for Developmental Biology in Japan.

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model